New insights in the pathogenesis of atopic dermatitis.

doi:10.1038/pr.2013.196

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Article

New insights in the pathogenesis of atopic dermatitis.

Pediatric research - 1 Jan 2014

Ong Peck Y

Abstract excerpt

Atopic dermatitis (AD) is characterized by skin barrier defects and increased interleukin (IL)-4/IL-13 expression. Recent evidence also suggests the involvement of innate immunity including Toll-like receptors, IL-33, IL-25, and innate lymphoid cells in the pathogenesis of AD. This article reviews these innate immune components and how they may become an integral part of prognostic factors and therapeutic targets...

Topics

Animals
Anti-Inflammatory Agents
Dermatitis, Atopic
Filaggrin Proteins
Genetic Predisposition to Disease
Humans
Immunity, Innate
Intermediate Filament Proteins
Keratinocytes
Mutation
Phenotype
Risk Factors
Skin

Source

Open in PubMed

Identifiers

PMID: 24192701
DOI: 10.1038/pr.2013.196

Provenance

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