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Article

The transcription factor EPAS1 links DOCK8 deficiency to atopic skin inflammation via IL-31 induction

9 Jan 2017

Abstract excerpt

Abstract Mutations ofDOCK8in humans cause a combined immunodeficiency characterized by atopic dermatitis with high serum IgE levels. However, the molecular link between DOCK8 deficiency and atopic skin inflammation is unknown. Here we show that CD4+T cells from DOCK8-deficient mice produce large amounts of IL-31, a major pruritogen associated with atopic dermatitis. IL-31 induction critically depends on the...

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PMID: 28067314
DOI: 10.1038/ncomms13946

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