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Article

Gating mechanism of elongating β-ketoacyl-ACP synthases.

Nature communications - 7 Apr 2020

Mindrebo Jeffrey T, Patel Ashay, Kim Woojoo E, Davis Tony D, Chen Aochiu, Bartholow Thomas G, La Clair James J, McCammon J Andrew, Noel Joseph P, Burkart Michael D

Abstract excerpt

Carbon-carbon bond forming reactions are essential transformations in natural product biosynthesis. During de novo fatty acid and polyketide biosynthesis, β-ketoacyl-acyl carrier protein (ACP) synthases (KS), catalyze this process via a decarboxylative Claisen-like condensation reaction. KSs must recognize multiple chemically distinct ACPs and choreograph a ping-pong mechanism, often in an iterative fashion....

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Acetyltransferases
Catalysis
Catalytic Domain
Crystallography, X-Ray
Hydrogen Bonding

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Hydrophobic and Hydrophilic Interactions

Molecular Dynamics Simulation

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PMID: 32265440
DOI: 10.1038/s41467-020-15455-x
PMCID: PMC7138838

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