Article
Reduced evolutionary rates in HIV-1 reveal extensive latency periods among replicating lineages.
Retrovirology - 16 Oct 2014
Immonen Taina T, Leitner Thomas
Abstract excerpt
BACKGROUND: HIV-1 can persist for the duration of a patient's life due in part to its ability to hide from the immune system, and from antiretroviral drugs, in long-lived latent reservoirs. Latent forms of HIV-1 may also be disproportionally involved in transmission. Thus, it is important to detect and quantify latency in the HIV-1 life cycle. RESULTS: We developed a novel molecular clock-based phylogenetic tool...
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