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Article

Toward reproducible, scalable, and robust data analysis across multiplex tissue imaging platforms.

Cell reports methods - 23 Aug 2021

Burlingame Erik A, Eng Jennifer, Thibault Guillaume, Chin Koei, Gray Joe W, Chang Young Hwan

Abstract excerpt

The emergence of megascale single-cell multiplex tissue imaging (MTI) datasets necessitates reproducible, scalable, and robust tools for cell phenotyping and spatial analysis. We developed open-source, graphics processing unit (GPU)-accelerated tools for intensity normalization, phenotyping, and microenvironment characterization. We deploy the toolkit on a human breast cancer (BC) tissue microarray stained by...

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Identifiers

PMID: 34485971
DOI: 10.1016/j.crmeth.2021.100053
PMCID: PMC8415641

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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