Article

Tribus: Semi-automated discovery of cell identities and phenotypes from multiplexed imaging and proteomic data

2024-03-14

Abstract excerpt

<h4>Motivation</h4> Multiplexed imaging and single-cell analysis are increasingly applied to investigate the tissue spatial ecosystems in cancer and other complex diseases. Accurate single-cell phenotyping based on marker combinations is a critical but challenging task due to (i) low reproducibility across experiments with manual thresholding, and, (ii) labor-intensive ground-truth expert annotation required for...

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Literature Corpus work: bbb6aba0-6b23-5e15-ab3a-5bb2e6d5022c
DOI: 10.1101/2024.03.13.584767

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