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Statistical Analysis of Multiplex Immunofluorescence and Immunohistochemistry Imaging Data.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2023

Wrobel Julia, Harris Coleman, Vandekar Simon

Abstract excerpt

Advances in multiplexed single-cell immunofluorescence (mIF) and multiplex immunohistochemistry (mIHC) imaging technologies have enabled the analysis of cell-to-cell spatial relationships that promise to revolutionize our understanding of tissue-based diseases and autoimmune disorders. Multiplex images are collected as multichannel TIFF files; then denoised, segmented to identify cells and nuclei, normalized...

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PMID: 36929077
DOI: 10.1007/978-1-0716-2986-4_8

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