Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Sex-dependent effects of amyloid precursor-like protein 2 in the SOD1-G37R transgenic mouse model of MND.

Cellular and molecular life sciences : CMLS - 1 Oct 2021

Truong Phan H, Crouch Peter J, Hilton James B W, McLean Catriona A, Cappai Roberto, Ciccotosto Giuseppe D

Abstract excerpt

Motor neurone disease (MND) is a neurodegenerative disorder characterised by progressive destruction of motor neurons, muscle paralysis and death. The amyloid precursor protein (APP) is highly expressed in the central nervous system and has been shown to modulate disease outcomes in MND. APP is part of a gene family that includes the amyloid precursor-like protein 1 (APLP1) and 2 (APLP2) genes. In the present...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amyloid beta-Protein Precursor
Share to Central Nervous System

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Motor Neuron Disease

Share to Motor Neurons

Share to Muscle Fibers, Skeletal

Share to Neuromuscular Junction

Share to Spinal Cord

Share to Superoxide Dismutase-1

Source

Open in PubMed Open full text

Identifiers

PMID: 34476545
DOI: 10.1007/s00018-021-03924-5
PMCID: PMC8558206

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Sex-dependent effects of amyloid precursor-like protein 2 in the SOD1-G37R transgenic mouse model of MND.PMID 34476545Read ↗

Sex Dependent Effects of Amyloid Precursor-Like Protein 2 in The SOD1-G37R Transgenic Mouse Model of MND.Semantic proximity Read ↗

Defective neuromuscular synapses in mice lacking amyloid precursor protein (APP) and APP-Like protein 2.Semantic proximity Read ↗

Loss ofALS2Function Is Insufficient to Trigger Motor Neuron Degeneration in Knock-Out Mice But Predisposes Neurons to Oxidative StressSemantic proximity Read ↗

Characterisation of the pathogenic effects of the in vivo expression of an ALS-linked mutation in D-amino acid oxidase: Phenotype and loss of spinal cord motor neurons.Semantic proximity Read ↗

Delineating sex-dependent and anatomic decline of motor functions in the SOD1G93A mouse model of amyotrophic lateral sclerosisSemantic proximity Read ↗

Neuronal deletion of MnSOD in mice leads to demyelination, inflammation and progressive paralysis that mimics phenotypes associated with progressive multiple sclerosis.Semantic proximity Read ↗

Progressive spinal axonal degeneration and slowness in ALS2-deficient mice.Semantic proximity Read ↗

Neurologic and motor dysfunctions in APP transgenic mice.Semantic proximity Read ↗

Motor neuron dysfunction in a mouse model of ALS: Gender-dependent effect of P2X7 antagonismSemantic proximity Read ↗

Embryonic expression pattern of amyloid protein precursor suggests a role in differentiation of specific subsets of neuronsSemantic proximity Read ↗

Genetic background and gender effects on gross phenotypes in congenic lines of ALS2/alsin-deficient mice.Semantic proximity Read ↗

Genetic background effects on disease onset and lifespan of the mutant dynactin p150Glued mouse model of motor neuron disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.