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Negative feedback by NUR77/Nr4a1 restrains B cell clonal dominance during early T-dependent immune responses

1 Aug 2021

Abstract excerpt

B cell clones compete for entry into and dominance within germinal centers (GCs), where the highest-affinity B cell receptors (BCRs) are selected. However, diverse and low-affinity B cells can enter and reside in GCs for extended periods. To reconcile these observations, we hypothesize that a negative feedback loop may operate within B cells to preferentially restrain high-affinity clones from monopolizing the...

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PMID: 34469720
DOI: 10.1016/j.celrep.2021.109645

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