Article
High-Order Epistasis and Functional Coupling of Infection Steps Drive Virus Evolution toward Independence from a Host Pathway.
Microbiology spectrum - 31 Oct 2021
Arita Minetaro
Abstract excerpt
The phosphatidylinositol-4 kinase IIIβ (PI4KB)/oxysterol-binding protein (OSBP) family I pathway serves as an essential host pathway for the formation of viral replication complex for viral plus-strand RNA synthesis; however, poliovirus (PV) could evolve toward substantial independence from this host pathway with four mutations. Recessive epistasis of the two mutations (3A-R54W and 2B-F17L) is essential for viral...
Topics
- Antiviral Agents
- Bacteriological Techniques
- Cell Death
- Epistasis, Genetic
- Evolution, Molecular
- Host-Pathogen Interactions
- Humans
- Mutation
- Poliovirus
- RNA, Viral
- Receptors, Steroid
- Virus Replication
- Oxysterol Binding Proteins