Article
Genetic regulation of spermine oxidase activity and cancer risk: a Mendelian randomization study.
Scientific reports - 31 Aug 2021
Fadista João, Yakimov Victor, Võsa Urmo, Hansen Christine S, Kasela Silva, Skotte Line, Geller Frank, Courraud Julie, Esko Tõnu, Kukuškina Viktorija, Buil Alfonso, Melbye Mads, Werge Thomas M, Hougaard David M, Milani Lili, Bybjerg-Grauholm Jonas, Cohen Arieh S, Feenstra Bjarke
Abstract excerpt
Spermine oxidase (SMOX) catalyzes the oxidation of spermine to spermidine. Observational studies have reported SMOX as a source of reactive oxygen species associated with cancer, implying that inhibition of SMOX could be a target for chemoprevention. Here we test causality of SMOX levels with cancer risk using a Mendelian randomization analysis. We performed a GWAS of spermidine/spermine ratio to identify genetic...
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