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Article

Mendelian randomization study of sleep traits and risk of colorectal cancer.

Scientific reports - 18 Apr 2025

Dimopoulou Olympia, Fuller Harriett, Richmond Rebecca C, Bouras Emmanouil, Hayes Bryony, Dimou Niki, Murphy Neil, Brenner Hermann, Gsur Andrea, Le Marchand Loic, Moreno Victor, Pai Rish K, Phipps Amanda I, Um Caroline Y, van Duijnhoven Franzel J B, Vodicka Pavel, Martin Richard M, Platz Elizabeth A, Gunter Marc J, Peters Ulrike, Lewis Sarah J, Cao Yin, Tsilidis Konstantinos K

Abstract excerpt

A potential association of endogenous circadian rhythm disruption with risk of cancer development has been suggested, however, epidemiological evidence for the association of sleep traits with colorectal cancer (CRC) is limited and often contradictory. Here we investigated whether genetically predicted chronotype, insomnia and sleep duration are associated with CRC risk in males, females and overall and according...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40251235
DOI: 10.1038/s41598-024-83693-w
PMCID: PMC12008275

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