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Article

Anticholinergic Medication Use, Dopaminergic Genotype, and Recurrent Falls.

The journals of gerontology. Series A, Biological sciences and medical sciences - 5 May 2022

Rosso Andrea L, Marcum Zachary A, Zhu Xiaonan, Bohnen Nicolaas, Rosano Caterina

Abstract excerpt

BACKGROUND: Anticholinergic medications are associated with fall risk. Higher dopaminergic signaling may provide resilience to these effects. We tested interactions between anticholinergic medication use and dopaminergic genotype on risk for recurrent falls over 10 years. METHODS: Participants in the Health, Aging, and Body Composition (Health ABC) study (n = 2 372, mean age = 73.6; 47.8% men; 60.0% White)...

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Identifiers

PMID: 34463739
DOI: 10.1093/gerona/glab258
PMCID: PMC9071487

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