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Article

Optimization of Sources of Circulating Cell-Free DNA Variability for Downstream Molecular Analysis.

The Journal of molecular diagnostics : JMD - 1 Nov 2021

Till Jacob E, Black Taylor A, Gentile Caren, Abdalla Aseel, Wang Zhuoyang, Sangha Hareena K, Roth Jacquelyn J, Sussman Robyn, Yee Stephanie S, O'Hara Mark H, Thompson Jeffrey C, Aggarwal Charu, Hwang Wei-Ting, Elenitoba-Johnson Kojo S J, Carpenter Erica L

Abstract excerpt

Circulating cell-free DNA (ccfDNA) is used increasingly as a cancer biomarker for prognostication, as a correlate for tumor volume, or as input for downstream molecular analysis. Determining optimal blood processing and ccfDNA quantification are crucial for ccfDNA to serve as an accurate biomarker as it moves into the clinical realm. Whole blood was collected from 50 subjects, processed to plasma, and used...

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Identifiers

PMID: 34454115
DOI: 10.1016/j.jmoldx.2021.08.007
PMCID: PMC8647427

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