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Article

Effects of Collection and Processing Procedures on Plasma Circulating Cell-Free DNA from Cancer Patients.

The Journal of molecular diagnostics : JMD - 1 Nov 2018

Risberg Bente, Tsui Dana W Y, Biggs Heather, Ruiz-Valdepenas Martin de Almagro Andrea, Dawson Sarah-Jane, Hodgkin Charlotte, Jones Linda, Parkinson Christine, Piskorz Anna, Marass Francesco, Chandrananda Dineika, Moore Elizabeth, Morris James, Plagnol Vincent, Rosenfeld Nitzan, Caldas Carlos, Brenton James D, Gale Davina

Abstract excerpt

Circulating tumor DNA (ctDNA) offers new opportunities for noninvasive cancer management. Detecting ctDNA in plasma is challenging because it constitutes only a minor fraction of the total cell-free DNA (cfDNA). Pre-analytical factors affect cfDNA levels contributed from leukocyte lysis, hence the ability to detect low-frequency mutant alleles. This study investigates the effects of the delay in processing,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 30165204
DOI: 10.1016/j.jmoldx.2018.07.005
PMCID: PMC6197164

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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