Article
Circulating Cell-Free DNA Yield and Circulating-Tumor DNA Quantity from Liquid Biopsies of 12 139 Cancer Patients.
Clinical chemistry - 1 Nov 2021
Huang Richard S P, Xiao Jinpeng, Pavlick Dean C, Guo Cui, Yang Lei, Jin Dexter X, Fendler Bernard, Severson Eric, Killian Jonathan Keith, Hiemenz Matthew, Duncan Daniel, Lin Douglas I, Dennis Lucas, Aiyer Aparna, Gjoerup Ole, Oxnard Geoff, Venstrom Jeffrey, Elvin Julia, Ramkissoon Shakti H, Ross Jeffrey S
Abstract excerpt
BACKGROUND: The amounts of circulating cell-free DNA (cfDNA) and circulating-tumor DNA (ctDNA) present in peripheral blood liquid biopsies can vary due to preanalytic/analytic variables. In this study, we examined the impact of patient age, sex, stage, and tumor type on cfDNA yield, ctDNA fraction, and estimated ctDNA quantity from a large cohort of clinical liquid biopsy samples. METHODS: We performed a...
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