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Mechanism and Effect of HNF4α Decrease in a Rat Model of Cirrhosis and Liver Failure

21 Nov 2023

Abstract excerpt

BACKGROUND & AIMS: HNF4α, a master regulator of liver development and the mature hepatocyte phenotype, is down-regulated in chronic and inflammatory liver disease. We used contemporary transcriptomics and epigenomics to study the cause and effects of this down-regulation and characterized a multicellular etiology. METHODS: Progressive changes in the rat carbon tetrachloride model were studied by deep RNA...

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PMID: 37993018
DOI: 10.1016/j.jcmgh.2023.11.009

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