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Article

The three common polymorphisms p.A986S, p.R990G and p.Q1011E in the calcium sensing receptor (CASR) are not associated with chronic pancreatitis.

Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] - 1 Oct 2021

Ewers Maren, Canaff Lucie, Weh Antonia Em, Masson Emmanuelle, Eiseler Katharina, Chen Jian-Min, Rebours Vinciane, Bugert Peter, Michl Patrick, Rosendahl Jonas, Férec Claude, Goltzman David, Witt Heiko

Abstract excerpt

BACKGROUND: The calcium sensing receptor (CASR) is a G protein-coupled receptor that is responsible for assessing extracellular Ca2+ levels and thus plays a crucial role in calcium homeostasis. Hypercalcemia is a metabolic risk factor for pancreatitis and rare CASR variants have been described in patients with chronic pancreatitis. At the carboxy-terminal tail of CASR, there is a cluster of three common...

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Identifiers

PMID: 34446336
DOI: 10.1016/j.pan.2021.08.008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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