Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

MAO-A Inhibition by Metaxalone Reverts IL-1β-Induced Inflammatory Phenotype in Microglial Cells.

International journal of molecular sciences - 5 Aug 2021

Pallio Giovanni, D'Ascola Angela, Cardia Luigi, Mannino Federica, Bitto Alessandra, Minutoli Letteria, Picciolo Giacomo, Squadrito Violetta, Irrera Natasha, Squadrito Francesco, Altavilla Domenica

Abstract excerpt

Experimental and clinical studies have suggested that several neurological disorders are associated with the occurrence of central nervous system neuroinflammation. Metaxalone is an FDA-approved muscle relaxant that has been reported to inhibit monoamine oxidase A (MAO-A). The aim of this study was to investigate whether metaxalone might exert antioxidant and anti-inflammatory effects in HMC3 microglial cells. An...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anti-Inflammatory Agents
Share to Interleukin-13

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Interleukin-1beta

Share to Interleukin-6

Share to Microglia

Share to Monoamine Oxidase

Share to Oxazolidinones

Share to PPAR gamma

Source

Open in PubMed Open full text

Identifiers

PMID: 34445126
DOI: 10.3390/ijms22168425
PMCID: PMC8395141

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

MAO-A Inhibition by Metaxalone Reverts IL-1β-Induced Inflammatory Phenotype in Microglial Cells.PMID 34445126Read ↗

Oxymatrine inhibits neuroinflammation byRegulating M1/M2 polarization in N9 microglia through the TLR4/NF-κB pathway.Semantic proximity Read ↗

Combination of EPA with Carotenoids and Polyphenol Synergistically Attenuated the Transformation of Microglia to M1 Phenotype Via Inhibition of NF-κB.Semantic proximity Read ↗

Antidepressant therapies inhibit inflammation and microglial M1-polarization.Semantic proximity Read ↗

Betaine Inhibits NLRP3 Inflammasome Hyperactivation and Regulates Microglial M1/M2 Phenotypic Differentiation, Thereby Attenuating Lipopolysaccharide-Induced Depression-Like Behavior.Semantic proximity Read ↗

The Novel Nrf2 Activator Omaveloxolone Regulates Microglia Phenotype and Ameliorates Secondary Brain Injury after Intracerebral Hemorrhage in Mice.Semantic proximity Read ↗

Pharmacological Blocker of NF-κb and Mitochondrial Ros Restrict NLRP3 Inflammasome Activation and Rescue Dopaminergic Neurons in Vitro and in Vivo Parkinson’s DiseaseSemantic proximity Read ↗

Naringenin Ameliorates LPS-Induced Neuroinflammation Through NF-κB Signaling in Human Microglia and Protects Neuronal CellsSemantic proximity Read ↗

Omega-3 Polyunsaturated Fatty Acids Protect Neurological Function After Traumatic Brain Injury by Suppressing Microglial Transformation to the Proinflammatory Phenotype and Activating Exosomal NGF/TrkA Signaling.Semantic proximity Read ↗

Omega-3 polyunsaturated fatty acids protect neurological function after traumatic brain injury by suppressing microglial transformation to the proinflammatory phenotype and activating exosomal NGF/TrkA signalingSemantic proximity Read ↗

C16 peptide and angiopoietin-1 protect against LPS-induced BV-2 microglial cell inflammation.Semantic proximity Read ↗

A novel small-molecule agonist of PPAR-γ potentiates an anti-inflammatory M2 glial phenotype.Semantic proximity Read ↗

Asperosaponin VI ameliorates the CMS-induced depressive-like behaviors by inducing a neuroprotective microglial phenotype in hippocampus via PPAR-γ pathway.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.