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Article

Variants Affecting the C-Terminal Tail of UNC93B1 Are Not a Common Risk Factor for Systemic Lupus Erythematosus.

Genes - 19 Aug 2021

Kiener Sarah, Ribi Camillo, Keller Irene, Chizzolini Carlo, Trendelenburg Marten, Huynh-Do Uyen, von Kempis Johannes, On Behalf Of Swiss Sle Cohort Study Sscs, Leeb Tosso

Abstract excerpt

Systemic lupus erythematosus (SLE) is a heterogeneous multifactorial disease. Upregulated TLR7 signaling is a known risk factor for SLE. Recently, it was shown that specific genetic variants in UNC93B1 affect the physiological regulation of TLR7 signaling and cause characteristic autoimmune phenotypes with monogenic autosomal recessive inheritance in mutant mice and dogs. We therefore hypothesized that homologous...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34440442
DOI: 10.3390/genes12081268
PMCID: PMC8392493

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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