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Article

Genetic loci contributing to hemophagocytic lymphohistiocytosis do not confer susceptibility to systemic-onset juvenile idiopathic arthritis.

Arthritis and rheumatism - 1 Mar 2008

Donn Rachelle, Ellison Stuart, Lamb Rebecca, Day Thomas, Baildam Eileen, Ramanan Athimalaipet V

Abstract excerpt

OBJECTIVE: To investigate whether single-nucleotide polymorphisms (SNPs) within the genes PRF1, GZMB, UNC13D, and Rab27a, which are involved in natural killer cell dysfunction and known to contribute to the risk of hemophagocytic lymphohistiocytosis (HLH), confer an increased risk of susceptibility to systemic-onset juvenile idiopathic arthritis (JIA). METHODS: Four SNPs across the PRF1 gene locus, 5 for GZMB, 7...

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Source

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Identifiers

PMID: 18311812
DOI: 10.1002/art.23270
PMCID: PMC2675009

Genes

GZMB
PRF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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