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Precision Anti-Inflammatory Therapy in Atherosclerosis: A Systematic Review and Meta-Analysis of Colchicine Timing and Clinical Outcomes in Patients with Atherosclerotic Cardiovascular Disease

2026-03-30

Abstract excerpt

<h4>Background</h4> Despite optimal lipid-lowering and antithrombotic therapy, substantial residual cardiovascular risk persists in established atherosclerotic cardiovascular disease (ASCVD), partly driven by chronic vascular inflammation through the NLRP3 inflammasome pathway. In an open-label pilot using colchicine 0.5 mg twice daily, hsCRP was reduced by approximately 60%. However, landmark trials report diver...

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Literature Corpus work
24e5b1fa-4a9f-5089-b87f-db62c9a7aa30
DOI
10.64898/2026.03.25.26348968
Open publication

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Precision Anti-Inflammatory Therapy in Atherosclerosis: A Systematic Review and Meta-Analysis of Colchicine Timing and Clinical Outcomes in Patients with Atherosclerotic Cardiovascular DiseaseDOI 10.64898/2026.03.25.26348968
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