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Article

Impact of evolocumab on plaque phenotypic changes in patients with acute coronary syndrome and elevated lipoprotein(a) levels: a HUYGENS secondary analysis.

European journal of preventive cardiology - 4 Sept 2026

Di Giovanni Giuseppe, Fujino Masashi, Kataoka Yu, Butters Julie, Hucko Thomas, Puri Rishi, Nissen Steven E, Nelson Adam J, Psaltis Peter J, Nicholls Stephen J

Abstract excerpt

AIMS: The proprotein convertase subtilisin/kexin Type 9 inhibitor, evolocumab, promoted plaque stabilization on serial imaging in patients following an acute coronary syndrome. The impact of evolocumab in patients with varying lipoprotein(a) [Lp(a)] levels is unknown. METHODS AND RESULTS: Serial optical coherence tomography imaging was performed to evaluate changes in plaque composition in response to treatment...

Read the complete abstract on PubMed

Topics

Humans
Lipoprotein(a)
Acute Coronary Syndrome
Antibodies, Monoclonal, Humanized
Female

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Male

Plaque, Atherosclerotic

Treatment Outcome

Tomography, Optical Coherence

Middle Aged

Phenotype

Biomarkers

Anticholesteremic Agents

Time Factors

Aged

Double-Blind Method

Cholesterol, LDL

Coronary Vessels

Source

Identifiers

PMID: 40424182
DOI: 10.1093/eurjpc/zwaf211

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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