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Article

The roles of history, chance, and natural selection in the evolution of antibiotic resistance.

eLife - 25 Aug 2021

Santos-Lopez Alfonso, Marshall Christopher W, Haas Allison L, Turner Caroline, Rasero Javier, Cooper Vaughn S

Abstract excerpt

History, chance, and selection are the fundamental factors that drive and constrain evolution. We designed evolution experiments to disentangle and quantify effects of these forces on the evolution of antibiotic resistance. Previously, we showed that selection of the pathogen Acinetobacter baumannii in both structured and unstructured environments containing the antibiotic ciprofloxacin produced distinct...

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Identifiers

PMID: 34431477
DOI: 10.7554/eLife.70676
PMCID: PMC8412936

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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