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Article

Genetics plays a limited role in predicting chronic obstructive pulmonary disease treatment response and exacerbation.

Respiratory medicine - 1 Oct 2021

Hosking Louise, Yeo Astrid, Hoffman Joshua, Chiano Mathias, Fraser Dana, Ghosh Soumitra, Lipson David A, Martin Neil, Condreay Lynn D, Cox Charles, St Jean Pamela

Abstract excerpt

BACKGROUND: Combination treatments, targeting multiple disease processes, benefit subjects with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). However, predicting treatment response and exacerbation risk remain challenging. OBJECTIVE: To identify genetic associations with AECOPD risk and response to combination therapy (fluticasone furoate, umeclidinium bromide and vilanterol). METHODS: The...

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Identifiers

PMID: 34428673
DOI: 10.1016/j.rmed.2021.106573

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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