Article
Pharmacological Management of Chronic Obstructive Lung Disease (COPD). Focus on Mutations - Part 1.
Current medicinal chemistry - 1 Jan 2019
Russo Patrizia, Lococo Filippo, Kisialiou Aliaksei, Prinzi Giulia, Lamonaca Palma, Cardaci Vittorio, Tomino Carlo, Fini Massimo
Abstract excerpt
BACKGROUND: We report a comprehensive overview of current Chronic Obstructive Lung Disease (COPD) therapies and discuss the development of possible new pharmacological approaches based on "new" knowledge. Specifically, sensitivity/resistance to corticosteroids is evaluated with a special focus on the role of gene mutations in drug response. OBJECTIVE: Critically review the opportunities and the challenges...
Topics
- Adrenal Cortex Hormones
- Drug Resistance
- Eosinophils
- Genome-Wide Association Study
- Humans
- Metabolomics
- Mutation
- Precision Medicine
- Proteomics
- Pulmonary Disease, Chronic Obstructive