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Article

Identification of a KLF5-dependent program and drug development for skeletal muscle atrophy

23 Aug 2021

Abstract excerpt

Significance Skeletal muscle atrophy occurs as a result of a variety of conditions including aging, disuse, and cachexia. In this study, we show that the transcription factor KLF5 is transiently up-regulated by metabolic and disuse stimulations and plays a pivotal role in the onset of muscle atrophy in vitro and in vivo. KLF5 physically interacts with Foxo1, and together, they regulate the transcription of Fbxo32...

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PMID: 34426497
DOI: 10.1073/pnas.2102895118

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