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Article

SARS-CoV-2 Delta Variant N Gene Mutations Reduce Sensitivity to the TaqPath COVID-19 Multiplex Molecular Diagnostic Assay.

Viruses - 16 Jun 2022

Holland Steven C, Bains Ajeet, Holland LaRinda A, Smith Matthew F, Sullins Regan A, Mellor Nicholas J, Thomas Alexis W, Johnson Nathaniel, Murugan Vel, Lim Efrem S

Abstract excerpt

As the SARS-CoV-2 virus evolves, mutations may result in diminished sensitivity to qRT-PCR diagnostic assays. We investigated four polymorphisms circulating in the SARS-CoV-2 Delta lineage that result in N gene target failure (NGTF) on the TaqPath COVID-19 Combo Kit. These mutations were detected from the SARS-CoV-2 genome sequences that matched with the diagnostic assay results of saliva specimens. Full length N...

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Identifiers

PMID: 35746787
DOI: 10.3390/v14061316
PMCID: PMC9228125

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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