Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Direct Interaction of Sox10 With Cadherin-19 Mediates Early Sacral Neural Crest Cell Migration: Implications for Enteric Nervous System Development Defects

20 Aug 2021

Abstract excerpt

BACKGROUND AND AIMS: The enteric nervous system, which regulates many gastrointestinal functions, is derived from neural crest cells (NCCs). Defective NCC migration during embryonic development may lead to enteric neuropathies such as Hirschsprung's disease (hindgut aganglionosis). Sox10 is known to be essential for cell migration but downstream molecular events regulating early NCC migration have not been fully...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Congenital gastrointestinal and neural anomalies
Share to Developmental Biology and Gene Regulation
Share to Spinal Dysraphism and Malformations

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 34425092
DOI: 10.1053/j.gastro.2021.08.029

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Direct Interaction of Sox10 With Cadherin-19 Mediates Early Sacral Neural Crest Cell Migration: Implications for Enteric Nervous System Development DefectsPMID 34425092Read ↗

The role of SOX10 during enteric nervous system development.Semantic proximity Read ↗

The developmental etiology and pathogenesis of Hirschsprung disease.Semantic proximity Read ↗

Enteric nervous system development: migration, differentiation, and diseaseSemantic proximity Read ↗

Identification of GLI Mutations in Patients With Hirschsprung Disease That Disrupt Enteric Nervous System Development in Mice.Semantic proximity Read ↗

“Too much guts and not enough brains”: (epi)genetic mechanisms and future therapies of Hirschsprung disease — a reviewSemantic proximity Read ↗

Single Cell Profiling in the <i> Sox10 <sup>Dom/+</sup> </i> Hirschsprung Mouse Implicates <i>Hoxa6</i> in Enteric Neuron Lineage AllocationSemantic proximity Read ↗

Combinatorial multiomic analysis from a pedigree of Sox10 <sup>Dom</sup> Hirschsprung mice implicates Dach1 as a modifier of Enteric Nervous System developmentSemantic proximity Read ↗

Sox10 mutation disrupts neural crest development in Dom Hirschsprung mouse model.Semantic proximity Read ↗

Hirschsprung disease: a developmental disorder of the enteric nervous systemSemantic proximity Read ↗

A distinct transcriptome characterizes neural crest-derived cells at the migratory wavefront during enteric nervous system developmentSemantic proximity Read ↗

Development of the enteric nervous system: bringing together cells, signals and genesSemantic proximity Read ↗

Building a brain in the gut: development of the enteric nervous systemSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.