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Combinatorial multiomic analysis from a pedigree of Sox10 <sup>Dom</sup> Hirschsprung mice implicates Dach1 as a modifier of Enteric Nervous System development

2025-11-04

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Hirschsprung disease (HSCR) is characterized by absence of enteric ganglia (aganglionosis) along variable lengths of the distal intestine. This disorder results from deficient colonization of fetal intestine by enteric neural crest-derived cells (ENCDCs). HSCR exhibits complex, multifactorial inheritance with penetrance and severity varying widely even within a family. SOX1...

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Literature Corpus work
523d99b3-dd1a-5fa3-8d88-024d3f8f48e6
DOI
10.1101/2025.11.02.686123
Open publication

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Combinatorial multiomic analysis from a pedigree of Sox10 <sup>Dom</sup> Hirschsprung mice implicates Dach1 as a modifier of Enteric Nervous System developmentDOI 10.1101/2025.11.02.686123
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