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RanGTP and the actin cytoskeleton keep paternal and maternal chromosomes apart during fertilization

23 Aug 2021

Abstract excerpt

Zygotes require two accurate sets of parental chromosomes, one each from the mother and the father, to undergo normal embryogenesis. However, upon egg-sperm fusion in vertebrates, the zygote has three sets of chromosomes, one from the sperm and two from the egg. The zygote therefore eliminates one set of maternal chromosomes (but not the paternal chromosomes) into the polar body through meiosis, but how the...

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PMID: 34424312
DOI: 10.1083/jcb.202012001

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