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Article

Single cell analysis of DNA in more than 10,000 individual sperm from men with abnormal reproductive outcomes.

Journal of assisted reproduction and genetics - 1 Nov 2021

Leung Angela Q, Bell Avery Davis, Mello Curtis J, Penzias Alan S, McCarroll Steven A, Sakkas Denny

Abstract excerpt

PURPOSE: This pilot study sought to (1) validate the use of a novel technology for single-sperm-cell genome sequencing (Sperm-seq) in infertile men who may not have optimal quantity or quality of sperm for genomic analysis and (2) compare these results to fertile donors. METHODS: Infertile men undergoing IVF with female partners with a previous history of failed fertilization with ICSI (FF) or poor blastulation...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 34417660
DOI: 10.1007/s10815-021-02300-3
PMCID: PMC8608944

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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