Article

SARS-CoV-2 escape <i>in vitro</i> from a highly neutralizing COVID-19 convalescent plasma

2020-12-28

Abstract excerpt

<h4>ABSTRACT</h4> To investigate the evolution of SARS-CoV-2 in the immune population, we co-incubated authentic virus with a highly neutralizing plasma from a COVID-19 convalescent patient. The plasma fully neutralized the virus for 7 passages, but after 45 days, the deletion of F140 in the spike N-terminal domain (NTD) N3 loop led to partial breakthrough. At day 73, an E484K substitution in the receptor-binding...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b7f77f5f-ce63-5973-ad33-9fc69bef60a4
DOI: 10.1101/2020.12.28.424451

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

SARS-CoV-2 escape <i>in vitro</i> from a highly neutralizing COVID-19 convalescent plasmaDOI 10.1101/2020.12.28.424451Read

SARS-CoV-2 escape from a highly neutralizing COVID-19 convalescent plasma.Semantic proximity Read

COVID-19 Serum Drives Spike-Mediated SARS-CoV-2 Variation.Semantic proximity Read

Reduced neutralization of SARS-CoV-2 variants by convalescent plasma and hyperimmune intravenous immunoglobulins for treatment of COVID-19Semantic proximity Read

ESC - a comprehensive resource for SARS-CoV-2 immune escape variantsSemantic proximity Read

Vaccination of COVID-19 Convalescent Plasma Donors Increases Binding and Neutralizing Antibodies Against SARS-CoV-2 VariantsSemantic proximity Read

ESC: a comprehensive resource for SARS-CoV-2 immune escape variants.Semantic proximity Read

Immune Evasion, Cell-Cell Fusion, and Spike Stability of the SARS-CoV-2 XEC Variant: Role of Glycosylation Mutations at the N-terminal DomainSemantic proximity Read

Landscape Analysis of Escape Variants Identifies SARS-CoV-2 Spike Mutations that Attenuate Monoclonal and Serum Antibody NeutralizationSemantic proximity Read

A proof of concept for neutralizing antibody-guided vaccine design against SARS-CoV-2Semantic proximity Read

REGEN-COV protects against viral escape in preclinical and human studiesSemantic proximity Read

Synthetic repertoires derived from convalescent COVID-19 patients enable discovery of SARS-CoV-2 neutralizing antibodies and a novel quaternary binding modalitySemantic proximity Read

Prevalent, protective, and convergent IgG recognition of SARS-CoV-2 non-RBD spike epitopes in COVID-19 convalescent plasmaSemantic proximity Read