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Article

A multicenter analysis of the prognostic value of histone H3 K27M mutation in adult high-grade spinal glioma.

Journal of neurosurgery. Spine - 1 Dec 2021

Akinduro Oluwaseun O, Garcia Diogo P, Higgins Dominique M O, Vivas-Buitrago Tito, Jentoft Mark, Solomon David A, Daniels David J, Pennington Zach, Sherman Wendy J, Delgardo Mychael, Bydon Mohamad, Kalani Maziyar A, Zanazzi George, Tsankova Nadejda, Bendok Bernard R, McCormick Paul C, Sciubba Daniel M, Lo Sheng-Fu Larry, Clarke Jennifer L, Abode-Iyamah Kingsley, Quiñones-Hinojosa Alfredo

Abstract excerpt

OBJECTIVE: High-grade spinal glioma (HGSG) is a rare but aggressive tumor that occurs in both adults and children. Histone H3 K27M mutation correlates with poor prognosis in children with diffuse midline glioma. However, the role of H3 K27M mutation in the prognosis of adults with HGSG remains unclear owing to the rarity of this mutation, conflicting reports, and the absence of multicenter studies on this topic....

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Identifiers

PMID: 34416733
DOI: 10.3171/2021.2.SPINE201675

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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