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Article

Clinical, molecular characteristics, and telomere-maintaining mechanism of spinal cord glioma with or without H3 K27M mutation: a prognostic and experimental study.

International journal of surgery (London, England) - 1 Feb 2026

Huang Haoxuan, Gou Yue, Kuang Yirui, Liu Chunbo, Wu Changwu, Tan Jun

Abstract excerpt

BACKGROUND: Spinal cord gliomas were rare, and their molecular characteristics, pathogenesis, and prognosis remain poorly understood. The 2021 WHO Classification introduced "Diffuse midline glioma, H3 K27-altered" (DMG) as a distinct entity, implicating H3 K27 alterations in DMG pathogenesis. However, molecular distinctions between H3 K27-altered and H3 K27 wild-type spinal cord glioma are underexplored. METHODS:...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 41217375
DOI: 10.1097/JS9.0000000000003818

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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