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Article

Clonal myelopoiesis promotes adverse outcomes in chronic kidney disease.

Leukemia - 1 Feb 2022

Dawoud Ahmed A Z, Gilbert Rodney D, Tapper William J, Cross Nicholas C P

Abstract excerpt

We sought to determine the relationship between age-related clonal hematopoiesis (CH) and chronic kidney disease (CKD). CH, defined as mosaic chromosome abnormalities (mCA) and/or driver mutations was identified in 5449 (2.9%) eligible UK Biobank participants (n = 190,487 median age = 58 years). CH was negatively associated with glomerular filtration rate estimated from cystatin-C (eGFR.cys; β = -0.75,...

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Share to Chromosome Aberrations
Share to Clonal Evolution
Share to Creatinine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cystatin C

Share to Glomerular Filtration Rate

Share to Mendelian Randomization Analysis

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Share to Renal Insufficiency, Chronic

Source

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Identifiers

PMID: 34413458
DOI: 10.1038/s41375-021-01382-3
PMCID: PMC8807385

Genes

ASXL1
CBL
DNMT3A
GNB1
JAK2
PPM1D
TET2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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