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Article

Determinants of maternal pregnancy one-carbon metabolism and newborn human DNA methylation profiles.

Reproduction (Cambridge, England) - 1 Dec 2014

van Mil Nina H, Bouwland-Both Marieke I, Stolk Lisette, Verbiest Michael M P J, Hofman Albert, Jaddoe Vincent W V, Verhulst Frank C, Eilers Paul H C, Uitterlinden Andre G, Steegers Eric A P, Tiemeier Henning, Steegers-Theunissen Régine P M

Abstract excerpt

Maternal one-carbon (1-C) metabolism provides methylgroups for fetal development and programing by DNA methylation as one of the underlying epigenetic mechanisms. We aimed to investigate maternal 1-C biomarkers, folic acid supplement use, and MTHFR C677T genotype as determinants of 1-C metabolism in early pregnancy in association with newborn DNA methylation levels of fetal growth and neurodevelopment candidate...

Read the complete abstract on PubMed

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Methylenetetrahydrofolate Reductase (NADPH2)

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Source

Identifiers

PMID: 25392189
DOI: 10.1530/REP-14-0260

Genes

MTHFR
DRD4
HTT

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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