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Article

Susceptibility loci and polygenic architecture highlight population specific and common genetic features in inguinal hernias: genetics in inguinal hernias.

EBioMedicine - 1 Aug 2021

Hikino Keiko, Koido Masaru, Tomizuka Kohei, Liu Xiaoxi, Momozawa Yukihide, Morisaki Takayuki, Murakami Yoshinori, The Biobank Japan Project, Mushiroda Taisei, Terao Chikashi

Abstract excerpt

BACKGROUND: The underlying pathology of inguinal hernia is still not fully known; thus, further investigations of genetic backgrounds is needed. Here, we aimed to identify genetic factors attributing to inguinal hernias and explore the polygenic architecture of which some components are population-specific, while others are more common among populations. METHODS: We performed a genome-wide association study...

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Identifiers

PMID: 34392144
DOI: 10.1016/j.ebiom.2021.103532
PMCID: PMC8374389

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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