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Article

A genome-wide association study identifies four novel susceptibility loci underlying inguinal hernia.

Nature communications - 21 Dec 2015

Jorgenson Eric, Makki Nadja, Shen Ling, Chen David C, Tian Chao, Eckalbar Walter L, Hinds David, Ahituv Nadav, Avins Andrew

Abstract excerpt

Inguinal hernia repair is one of the most commonly performed operations in the world, yet little is known about the genetic mechanisms that predispose individuals to develop inguinal hernias. We perform a genome-wide association analysis of surgically confirmed inguinal hernias in 72,805 subjects (5,295 cases and 67,510 controls) and confirm top associations in an independent cohort of 92,444 subjects with...

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Identifiers

PMID: 26686553
DOI: 10.1038/ncomms10130
PMCID: PMC4703831

Genes

EFEMP1
ADAMTS6
EBF2

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