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Article

Dystrophin involvement in peripheral circadian SRF signalling

13 Aug 2021

Abstract excerpt

Absence of dystrophin, an essential sarcolemmal protein required for muscle contraction, leads to the devastating muscle-wasting disease Duchenne muscular dystrophy. Dystrophin has an actin-binding domain, which binds and stabilises filamentous-(F)-actin, an integral component of the RhoA-actin-serum-response-factor-(SRF) pathway. This pathway plays a crucial role in circadian signalling, whereby the...

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PMID: 34389686
DOI: 10.26508/lsa.202101014

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