Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

High Frequency Hearing Loss and Hyperactivity in DUX4 Transgenic Mice.

PloS one - 1 Jan 2016

Dandapat Abhijit, Perrin Benjamin J, Cabelka Christine, Razzoli Maria, Ervasti James M, Bartolomucci Alessandro, Lowe Dawn A, Kyba Michael

Abstract excerpt

Facioscapulohumeral muscular dystrophy (FSHD) is caused by mutations leading to ectopic expression of the transcription factor DUX4, and encompasses both muscle-related and non-muscle phenotypes. Mouse models bearing this gene represent valuable tools to investigate which pathologies are due to DUX4 expression, and how DUX4 leads to these pathologies. The iDUX4(2.7) mouse contains an X-linked...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Body Composition
Share to Doxycycline
Share to Failure to Thrive

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genes, Lethal

Share to Hyperkinesis

Share to Respiration Disorders

Share to Transgenes

Share to X Chromosome Inactivation

Source

Open in PubMed Open full text

Identifiers

PMID: 26978271
DOI: 10.1371/journal.pone.0151467
PMCID: PMC4792399

Genes

DUX4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

High Frequency Hearing Loss and Hyperactivity in DUX4 Transgenic Mice.PMID 26978271Read ↗

Transgenic mice expressing tunable levels of DUX4 develop characteristic facioscapulohumeral muscular dystrophy-like pathophysiology ranging in severity.Semantic proximity Read ↗

A cre-inducible DUX4 transgenic mouse model for investigating facioscapulohumeral muscular dystrophy.Semantic proximity Read ↗

Transgenic mice expressing tunable levels of DUX4 develop characteristic facioscapulohumeral muscular dystrophy-like pathophysiology ranging in severitySemantic proximity Read ↗

Muscle pathology from stochastic low level DUX4 expression in an FSHD mouse model.Semantic proximity Read ↗

Transgenic mouse models for investigating human <i>DUX4</i> expression during development and its roles in FSHD pathophysiologySemantic proximity Read ↗

Dominant lethal pathologies in male mice engineered to contain an X-linked DUX4 transgene.Semantic proximity Read ↗

Biphasic myopathic phenotype of mouse DUX, an ORF within conserved FSHD-related repeats.Semantic proximity Read ↗

Mouse Dux is myotoxic and shares partial functional homology with its human paralog DUX4Semantic proximity Read ↗

Transgenic Drosophila for Investigating DUX4 and FRG1, Two Genes Associated with Facioscapulohumeral Muscular Dystrophy (FSHD).Semantic proximity Read ↗

<i>DUX4</i>, a candidate gene for facioscapulohumeral muscular dystrophy, causes p53‐dependent myopathy in vivoSemantic proximity Read ↗

An isogenetic myoblast expression screen identifies DUX4-mediated FSHD-associated molecular pathologies.Semantic proximity Read ↗

Alterations in background ECoG activity and behavioral deficits in a mouse model of CHD2-related developmental delaySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.