Article

Dystrophin regulates peripheral circadian SRF signalling

2021-06-23

Abstract excerpt

Dystrophin is a sarcolemmal protein essential for muscle contraction and maintenance, absence of which leads to the devastating muscle wasting disease Duchenne muscular dystrophy (DMD)[1, 2]. Dystrophin has an actin-binding domain [3–5], which specifically binds and stabilises filamentous (F)-actin[6], an integral component of the RhoA-actin-serum response factor (SRF)-pathway[7]. The RhoA-actin-SRF-pathway plays...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 59114e5e-0ce0-53f2-b04e-2413813afd7e
DOI: 10.1101/2021.06.23.449492

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Dystrophin regulates peripheral circadian SRF signallingDOI 10.1101/2021.06.23.449492Read

Dystrophin involvement in peripheral circadian SRF signallingSemantic proximity Read

Dystrophin deficiency disrupts muscle clock expression and mitochondrial quality control in mdx miceSemantic proximity Read

Circadian rhythms, the molecular clock, and skeletal muscle.Semantic proximity Read

The ER-bound RING finger protein 5 (RNF5/RMA1) causes degenerative myopathy in transgenic mice and is deregulated in inclusion body myositis.Semantic proximity Read

Identification of the circadian transcriptome in adult mouse skeletal muscle.Semantic proximity Read

Metabolic remodeling of dystrophic skeletal muscle reveals biological roles for dystrophin and utrophin in adaptation and plasticitySemantic proximity Read

SMAD signaling drives heart and muscle dysfunction in a Drosophila model of muscular dystrophySemantic proximity Read

Intrinsic muscle clock is necessary for musculoskeletal health.Semantic proximity Read

Time- and exercise-dependent gene regulation in human skeletal muscleSemantic proximity Read

High Frequency Hearing Loss and Hyperactivity in DUX4 Transgenic Mice.Semantic proximity Read

Expression and regulation of Homer in human skeletal muscle during neuromuscular junction adaptation to disuse and exerciseSemantic proximity Read

Regulation of STARS and its downstream targets suggest a novel pathway involved in human skeletal muscle hypertrophy and atrophySemantic proximity Read