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Regulatable Gene Expression Systems for Gene Therapy

24 Jul 2006

Abstract excerpt

It is feasible to restrict transgene expression to a tissue or region in need of therapy by using promoters that respond to focusable physical stimuli. The most extensively investigated promoters of this type are radiation-inducible promoters and heat shock protein gene promoters that can be activated by directed, transient heat. Temporal regulation of transgenes can be achieved by various two- or three-component...

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PMID: 16918333
DOI: 10.2174/156652306777934829

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