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Article

Biological basis for efficacy of activin receptor ligand traps in myelodysplastic syndromes

20 Jan 2020

Abstract excerpt

Signaling by the TGF-β superfamily is important in the regulation of hematopoiesis and is dysregulated in myelodysplastic syndromes (MDSs), contributing to ineffective hematopoiesis and clinical cytopenias. TGF-β, activins, and growth differentiation factors exert inhibitory effects on red cell formation by activating canonical SMAD2/3 pathway signaling. In this Review, we summarize evidence that overactivation...

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PMID: 31961337
DOI: 10.1172/jci133678

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