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Article

Three optimized assays for the evaluation of compounds that can rescue p53 mutants.

STAR protocols - 17 Sept 2021

Wu Jiale, Song Huaxin, Wang Zhengyuan, Lu Min

Abstract excerpt

Identifying drugs targeting p53 remains a major focus of precision oncology, with over twenty compounds that can rescue p53 mutants reported. Here, we suggest three easily accessible assays to determine the thermostability, protein folding, and transcriptional activity of p53 mutants-the go-to criteria for evaluating a rescue compound that acts by increasing p53 thermostability. Because of the diversity of p53...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 34382015
DOI: 10.1016/j.xpro.2021.100688
PMCID: PMC8339244

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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