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Article

Substitution of I222L-E119V in neuraminidase from highly pathogenic avian influenza H7N9 virus exhibited synergistic resistance effect to oseltamivir in mice.

Scientific reports - 11 Aug 2021

Tang Jing, Gao Rongbao, Liu Liqi, Zhang Shuxia, Liu Jia, Li Xiyan, Fang Qiongqiong, Feng Zhaomin, Xu Cuiling, Huang Weijuan, Wang Dayan

Abstract excerpt

That the high frequency and good replication capacity of strains with reduced susceptibility to neuraminidase inhibitors (NAIs) in highly pathogenic avian influenza H7N9 (HPAI H7N9) virus made it a significance to further study its drug resistance. HPAI H7N9 viruses bearing NA I222L or E119V substitution and two mutations of I222L-E119V as well as their NAIs-sensitive counterpart were generated by reverse...

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Identifiers

PMID: 34381119
DOI: 10.1038/s41598-021-95771-4
PMCID: PMC8358046

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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