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Intermolecular Mechanism and Dynamic Investigation of Avian Influenza H7N9 Virus' Susceptibility to E119V-Substituted Peramivir-Neuraminidase Complex.

Molecules (Basel, Switzerland) - 2 Mar 2022

Mtambo Sphamandla E, Ugbaja Samuel C, Mushebenge Aganze G, Abubakar Bahijjahtu H, Ntuli Mthobisi L, Kumalo Hezekiel M

Abstract excerpt

The H7N9 virus attaches itself to the human cell receptor protein containing the polysaccharide that terminates with sialic acid. The mutation of neuraminidase at residue E119 has been explored experimentally. However, there is no adequate information on the substitution with E119V in peramivir at the intermolecular level. Therefore, a good knowledge of the interatomic interactions is a prerequisite in...

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PMID: 35268741
DOI: 10.3390/molecules27051640
PMCID: PMC8911867

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