Article
Low replicative fitness of neuraminidase inhibitor-resistant H7N9 avian influenza a virus with R292K substitution in neuraminidase in cynomolgus macaques compared with I222T substitution.
Antiviral research - 1 Jun 2020
Suzuki Saori, Shichinohe Shintaro, Itoh Yasushi, Nakayama Misako, Ishigaki Hirohito, Mori Yuya, Ogata-Nakahara Ayako, Nguyen Cong Thanh, Okamatsu Masatoshi, Sakoda Yoshihiro, Kida Hiroshi, Ogasawara Kazumasa
Abstract excerpt
Human cases of H7N9 influenza A virus infection have been increasing since 2013. The first choice of treatment for influenza is neuraminidase (NA) inhibitors (NAIs), but there is a concern that NAI-resistant viruses are selected in the presence of NAIs. In our previous study, an H7N9 virus carrying AA substitution of threonine (T) for isoleucine (I) at residue 222 in NA (NA222T, N2 numbering) and an H7N9 virus...
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