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Contrasting genomic profiles from metastatic sites, primary tumors, and liquid biopsies of advanced prostate cancer.

Cancer - 15 Dec 2021

Necchi Andrea, Cucchiara Vito, Grivas Petros, Bratslavsky Gennady, Jacob Joseph, Spiess Philippe E, Sokol Ethan S, Killian Jonathan Keith, Lin Douglas, Ramkissoon Shakti, Huang Richard S P, Madison Russell W, Venstrom Jeffrey M, Schrock Alexa B, Danziger Natalie, Decker Brennan, Gjoerup Ole, Graf Ryon P, Oxnard Geoffrey R, Tukachinsky Hanna, Ross Jeffrey S

Abstract excerpt

BACKGROUND: This study assessed the contrasting genomic profiles from the primary tumors (PTs), metastatic (MET) sites, and circulating tumor DNA (ctDNA) of patients with prostate cancer (PC). METHODS: A total of 1294 PC tissue specimens and 2462 ctDNA specimens underwent hybrid capture-based comprehensive genomic profiling (CGP). Specimens included tissue from PTs; MET biopsies from bone, liver (LIV), lung (LU),...

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Identifiers

PMID: 34379803
DOI: 10.1002/cncr.33865

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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