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Article

Genetic architecture of routinely acquired blood tests in a British South Asian cohort.

Nature communications - 16 Oct 2024

Jacobs Benjamin M, Stow Daniel, Hodgson Sam, Zöllner Julia, Samuel Miriam, Kanoni Stavroula, Bidi Saeed, Walter Klaudia, Langenberg Claudia, Dobson Ruth, Finer Sarah, Morton Caroline, Siddiqui Moneeza K, Martin Hilary C, Pietzner Maik, Mathur Rohini, van Heel David A

Abstract excerpt

Understanding the genetic basis of routinely-acquired blood tests can provide insights into several aspects of human physiology. We report a genome-wide association study of 42 quantitative blood test traits defined using Electronic Healthcare Records (EHRs) of ~50,000 British Bangladeshi and British Pakistani adults. We demonstrate a causal variant within the PIEZO1 locus which was associated with alterations in...

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Identifiers

PMID: 39414775
DOI: 10.1038/s41467-024-53091-x
PMCID: PMC11484750

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